Shoot Up or Put Up

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Avatar of Alison

by Alison

Should we go all out for a cure?

8 October, 2012 in Living with diabetes, The future

I was at a meeting a few weeks ago when discussion wandered onto the artificial pancreas. How we’re making progress towards it, how it’d be great if they could get it controlling blood sugars automatically overnight, but how more complex manoeuvres like dealing with food and exercise will be more of a challenge. And of course it’ll never be as good as an old fashioned, homegrown, organic pancreas.

Then someone asked a question. Rather than getting distracted by imperfect solutions like the artificial pancreas, shouldn’t we be focusing all of our efforts on a cure. That’s surely what we really need and want?

In theory, I’d agree. If the pancreas pixie came tomorrow and waved her magic wand, I’d be delighted of course. Or if there was any truth in the emails I receive telling me that a week spent doing yoga in a shed in Spain would cure my diabetes, I’d give it a go. But brace yourselves readers, it’s time to face reality, I don’t think it’s as simple as that.

I have a problem with the “all out for a cure” approach. Firstly the psychology of it worries me. My pancreas has been faulty for nearly 30 years. What a miserable life that would have been if I’d spent it praying, hoping, yearning for a cure. Convinced that it was only ever that mythical 10 years away, as it was in 1984 and has been ever since. Instead I tend to see a cure in the same vein as I view a multi-million pound lottery win. Theoretically possible, but not something I factor in when planning my life. That means that financially I look for other ways of making money, and healthwise I accept my pancreas is dodgy and focus my efforts on living really well with diabetes today.

One of the problems with diabetes is that for most people, it’s not bad enough to cure. If I were dying, had been given a year to live, I’d probably do anything to be cured. I’d risk life and limb, try anything with the slightest chance of success – what have I got to lose?

But thankfully I’m not in that position. I have an irritating disease which has the potential to ruin lives, but in most cases, with good care and a following wind can be controlled. That makes me fussy. It makes me look at potential “cures” like pancreas and islet cell transplants with the accompanying lifetime of immunosuppressant drugs and think for me, right now, they’re not worth the risk. My life is good, why risk it? Would I feel differently if I had severe complications? Probably.

The dictionary definition of a cure talks about something that will “eliminate (a disease or condition) with medical treatment”. In very few cases do we actually cure anything. We can beat cancer into remission, but its only in fundraising ads that we talk about it being cured. We can eradicate diseases like polio in entire populations, but we’re not so hot at curing it once you’ve got it.

I don’t mean to depress you. I’m just trying to look at this practically. So to answer the original question, no, I don’t think we should be putting all our efforts into finding a cure. I believe our primary focus should be on improving the excellent treatments we already have, and more importantly, making sure everyone has access to them. Yes, let’s invest in looking for a cure – you never know what’s out there, we may discover that amputating my left little toe would jump start my pancreas and life would return to normal. But let’s make that the secondary aim, with the primary one being to enable people to live well with diabetes today. Without that, the last 30 years for me would have been bloody miserable ones. What do you think?

Peninsula researchers’ defective gene may help diabetics

13 December, 2011 in news, The future

A study of people born without a pancreas has provided a “key” which could help those with Type 1 diabetes. The discovery of a defective gene – GATA6 – was made by Peninsula College of Medicine and Dentistry researchers at the University of Exeter.

This dog always likes stories about diabetes breakthroughs but sometimes thinks they always seem to be early research and never finished research. Woof!

Source: http://betes.co.uk/yx7qt

Avatar of Tim

by Tim

I wish I was a diabetic mouse

25 November, 2011 in Mildly amusing, The future

A diabetic mouse - cured yesterday

A diabetic mouse - cured yesterday

As I sit each morning over my toast and marmalade appraising the latest edition of The Times propped up against the teapot – the warming scent of lapsang souchong drifting through the air – my eye is often drawn to the latest medical developments in the wild world of diabetes research.

In general I think diabetes research is great. After all, if our old friend Fred Banting hadn’t had an interest in isolating insulin back in 1922 the readership (and, indeed, authorship) of this blog would be considerably lower than it is now.

However, I do think there is a considerable bias in diabetes research – not towards type one or type two or anything like that. No, there’s huge favouritism in terms of time, effort and funding towards researching a cure for diabetic mice.

Every single day there are reports some new breakthrough that gives a new lease of life to those rodenty balls of fluff. Take for example the following I found via Google News merely seconds ago:

Compound blocks diabetes 1 progress in mice & human cells
Researchers at the University of Colorado School of Medicine have found a molecule that can prevent the development of type 1 diabetes in mice
[Source: http://www.prohealth.com/library/showarticle.cfm?libid=16614]

Barbara Davis Center researcher reveals treatment for type 1 diabetes preventing the disease in mice
Aaron Michels was ecstatic when, a few months ago, he found that a drug-like molecule could prevent the development of type 1 diabetes in mice.
[Source: http://www.aurorasentinel.com/hp_living/article_9e6c19fc-0c77-11e1-bafb-001cc4c002e0.html]

Rooibos shows promise in curbing diabetes
Japanese scientists found that rooibos helps improve the glucose uptake of muscle cells, thereby maintaining normal blood sugar levels in diabetic mice
[Source: http://www.health24.com/news/Diabetes/1-904,71502.asp]

Diabetes in Lab Mice Reversed with Natural Compound
A team of researchers in the United States reported recently that it was able to cure Type 2 diabetes in mice.
[Source: http://www.voanews.com/english/news/health/Diabetes-in-Lab-Mice-Reversed-with-Natural-Compound-133994108.html]

And there were plenty more where they came from!

Looking through these and other stories it’s clear that researchers have a fixation with treating our diabetic cheese-eating fiends. I wonder why? It’s not as if anyone really likes mice is it? A few years ago my old flat had a mouse and I spent weeks trying my best to kill it (I eventually succeeded, but it got its revenge by dying behind the fridge where I couldn’t get to it – filling the flat with the fetid smell of slowly decomposing mouse. Clearly it had the last laugh). No one cares about the rising type two epidemic in obese mice and no one campaigns for tiny ickle insulin pumps for rodents either.

So come on boffins – pull your fingers out, stop curing mice and start curing humans!

Avatar of Alison

by Alison

Want to get involved in diabetes research?

7 October, 2011 in news, The future

For researchers looking to investigate something around diabetes, the first challenge can often be finding some suitable guinea pigs to experiment on. Some might have a friendly hospital diabetic clinic who’ll let them speak to their patients, but most pancreatically challenged types are treated by GP’s, and aren’t so easy to get hold of.

Help Diabeates (bonus points awarded for clever integration of “beat” and “diabetes” to give puntastic name) is a campaign being run by the Diabetes Research Network and supported by the great and the good of the diabetes charity world. Its aim is to try and get a larger pool of diabetic types involved in research projects.

On the site you can register your interest in taking part in diabetes related research. Disappointingly, you’re not signing up to be randomly allocated to trials, kind of like a research Russian roulette where at the click of a mouse you’ve committed to having a leg chopped off to see if that helps your control or having your insulin withheld for a week to see what that does to you.  That’s not the case at all. Rather boringly, you just give your contact details and a friendly soul from the NHS will give you a call to chat about how you might be able to help – if you’re a pumper you’re obviously going to be interested in different research projects compared to if you’re Type 2 on diet. Once they’ve had a high level chat they’ll ask whether you’d be happy to be approached to take part in any suitable studies. You’re basically joining a mailing list.

I’ve signed up. I have nothing to lose by knowing what projects are going on and volunteering to be a guinea pig for any that particularly appeal. If you’d like to do the same, click here.

[Tim edit - Alison's evident Anglo-centric bias neglected to note that this is only for patients in England. But Scotland has a similar thing here: http://www.ukdrn.org/patients_involved.html. Tim's evident Alba-centric bias neglects to care what they do in Wales or Northern Ireland.]